Section: New Software and Platforms

Platforms

The deformable cell model [123], [52] has been integrated in addition to the center-based model in the software TiSim (Tissue Simulator), a follow-up of former CellSys [113]. Center-based models of cells represent forces between cells as forces between cell centers but lacks an explicit representation of cell shape. The deformable cell model represents cell shape explicitly. Applications are monolayers, multicellular spheroids and simulations of liver regeneration, whereby intracellular pathways can be integrated. The model shall be distributed as binary and will permit to use the deformable cell model to calibrate intercellular forces at high cell densities, where the two-body force models so far applied in center-based models fail.

This image processing and analysis software ( [103]) now integrates a machine learning component. This is fundamental as it is more general and permits quicker adaptation to new images.